Interventions for autumn exacerbations of asthma in children

The objectives are as follows: To assess the effects of pharmacotherapy and behavioural interventions enacted in the lead-up to the school return during autumn which are designed to reduce asthma exacerbations in school-aged children during this period

Developmental Changes in Infants' Categorization of Anger and Disgust Facial Expressions

For decades, scholars have examined how children first recognize emotional facial expressions. This research has found that infants younger than 10 months can discriminate negative, within-valence facial expressions in looking time tasks, and children older than 24 months struggle to categorize these expressions in labeling and free-sort tasks. Specifically, these older children, and even adults, consistently misidentify disgust expressions as anger. Although some scholars have hypothesized that young infants would also be unable to categorize anger and disgust expressions, this question has not been empirically tested. In addition, very little research has examined developmental changes in infants' perceptual categorization abilities with high arousal, within-valence emotions. For this reason, the current study tested 10- and 18-month-olds in a looking time task and found that both age groups could perceptually categorize anger and disgust facial expressions. Furthermore, 18-month-olds showed a heightened sensitivity to novel anger expressions, suggesting that, over the second year of life, infants' emotion categorization skills undergo developmental change. These findings are the first to demonstrate that young infants can categorize anger and disgust facial expressions and to document how this skill develops and changes over time

Performance analysis of cooperative and non-cooperative relaying over VLC channels

The line-of-sight (LoS) channel is one of the requirements for efficient data transmission in visible-light communications (VLC), but this cannot always be guaranteed in indoor applications for a variety of reasons, such as moving objects and the layout of rooms. The relay-assisted VLC system is one of the techniques that can be used to address this issue and ensures seamless connectivity. This paper investigates the performance of half-duplex (HD) conventional DF relay system and cooperative systems (i.e., selective DF (SDF) and incremental DF (IDF)) over VLC channels in terms of outage probability and energy consumption. Analytical expressions for both outage probability and the minimum energy-per-bit performance of the aforementioned relaying systems are derived. Furthermore, Monte Carlo simulations are provided throughout the paper to validate the derived expressions. The results show that exploiting SDF and IDF relaying schemes can achieve approximately 25% and 15% outage probability enhancement compared to single-hop and DF protocols, respectively. The results also demonstrate that the performance of the single-hop VLC system deteriorates when the end-to-end distances become larger. For example, when the vertical distance is 3.5m, the single-hop approach consumes 20%, 40% and 45% more energy in comparison to the DF, SDF, and IDF approaches, respectively

Channel modeling for overhead line equipment for train communication

The demand for high-speed data access to railway infrastructure and internet broadband data in railway is increasing due to the high density of the trains and passengers. Currently, communication access in trains is based on radio frequency (RF) wireless access networks that are slow and insufficient for the demands of the high-speed railway (HSR) and its customers. However, performance, service attributes, frequency band, and industrial support should be considered for the selection of a suitable communication system that can fulfill the requirements of HSR operation. This paper investigates overhead line equipment (OLE) as access network connecting trains to the backbone communication networks. The ABCD transmission model is used to represent the transfer function of the OLE channel. It was shown that transmission over OLE is affected by the frequency and link distance. The simulation results also show that the channel gain of the OLE channel attenuated faster at higher speeds compared to train movement at lower speeds

On the performance of DF-based power-line/visible-light communication systems

This paper presents a comprehensive performance analysis of an integrated indoor power line communication (PLC)/visible light communication (VLC) system with the presence of a decode-and-forward (DF) relay. The existing indoor power line networks are used as the backbone for VLCs. The performance of the proposed system is evaluated in terms of the average capacity and the outage probability. A new unified mathematical method is developed for the PLC/VLC system and analytical expressions for the aforementioned performance metrics are derived. Monte Carlo simulations are provided throughout the paper to verify the correctness of the analysis. The results reveal that the performance of the proposed system deteriorates with increasing the end-to-end distance and improves with increasing the relay transmit power. It is also shown that the outage probability of the system under consideration is negatively affected by the vertical distance to user plane

Transoral laser surgery for laryngeal carcinoma: has Steiner achieved a genuine paradigm shift in oncological surgery?

Transoral laser microsurgery applies to the piecemeal removal of malignant tumours of the upper aerodigestive tract using the CO2 laser under the operating microscope. This method of surgery is being increasingly popularised as a single modality treatment of choice in early laryngeal cancers (T1 and T2) and occasionally in the more advanced forms of the disease (T3 and T4), predomi- nantly within the supraglottis. Thomas Kuhn, the American physicist turned philosopher and historian of science, coined the phrase ‘paradigm shift’ in his groundbreaking book The Structure of Scientific Revolutions. He argued that the arrival of the new and often incompatible idea forms the core of a new paradigm, the birth of an entirely new way of thinking. This article discusses whether Steiner and col- leagues truly brought about a paradigm shift in oncological surgery. By rejecting the principle of en block resection and by replacing it with the belief that not only is it oncologically safe to cut through the substance of the tumour but in doing so one can actually achieve better results, Steiner was able to truly revolutionise the man- agement of laryngeal cancer. Even though within this article the repercussions of his insight are limited to the upper aerodigestive tract oncological surgery, his willingness to question other peoples’ dogma makes his contribution truly a genuine paradigm shift

The impact of consent on observational research: a comparison of outcomes from consenters and non consenters to an observational study

Background Public health benefits from research often rely on the use of data from personal medical records. When neither patient consent nor anonymisation is possible, the case for accessing such records for research purposes depends on an assessment of the probabilities of public benefit and individual harm. Methods In the late 1990s, we carried out an observational study which compared the care given to affluent and deprived women with breast cancer. Patient consent was not required at that time for review of medical records, but was obtained later in the process prior to participation in the questionnaire study. We have re-analysed our original results to compare the whole sample with those who later provided consent. Results Two important findings emerged from the re-analysis of our data which if presented initially would have resulted in insufficient and inaccurate reporting. Firstly, the reduced dataset contains no information about women presenting with locally advanced or metastatic cancer and we would have been unable to demonstrate one of our initial key findings: namely a larger number of such women in the deprived group. Secondly, our re-analysis of the consented women shows that significantly more women from deprived areas (51 v 31%, p = 0.018) received radiotherapy compared to women from more affluent areas. Previously published data from the entire sample demonstrated no difference in radiotherapy treatment between the affluent and deprived groups. Conclusion The risk benefit assessment made regarding the use of medical records without consent should include the benefits of obtaining research evidence based on 100% of the population and the possibility of inappropriate or insufficient findings if research is confined to consented populations

G-quadruplex DNA motifs in the malaria parasite Plasmodium falciparum and their potential as novel antimalarial drug targets

G-quadruplexes are DNA or RNA secondary structures that can be formed from guanine-rich nucleic acids. These four-stranded structures, composed of stacked quartets of guanine bases, can be highly stable and have been demonstrated to occur in vivo in the DNA of human cells and other systems, where they play important biological roles, influencing processes such as telomere maintenance, DNA replication and transcription, or, in the case of RNA G-quadruplexes, RNA translation and processing. We report for the first time that DNA G-quadruplexes can be detected in the nuclei of the malaria parasite Plasmodium falciparum, which has one of the most A/T-biased genomes sequenced and therefore possesses few guanine-rich sequences with the potential to form G-quadruplexes. We show that despite this paucity of putative G-quadruplex-forming sequences, P. falciparum parasites are sensitive to several G-quadruplex-stabilizing drugs, including quarfloxin, which previously reached phase 2 clinical trials as an anticancer drug. Quarfloxin has a rapid initial rate of kill and is active against ring stages as well as replicative stages of intraerythrocytic development. We show that several G-quadruplex-stabilizing drugs, including quarfloxin, can suppress the transcription of a G-quadruplex-containing reporter gene in P. falciparum but that quarfloxin does not appear to disrupt the transcription of rRNAs, which was proposed as its mode of action in both human cells and trypanosomes. These data suggest that quarfloxin has potential for repositioning as an antimalarial with a novel mode of action. Furthermore, G-quadruplex biology in P. falciparum may present a target for development of other new antimalarial drugs

Fission stories: using PomBase to understand Schizosaccharomyces pombe biology

PomBase (www.pombase.org), the model organism database (MOD) for the fission yeast Schizosaccharomyces pombe, supports research within and beyond the S. pombe community by integrating and presenting genetic, molecular, and cell biological knowledge into intuitive displays and comprehensive data collections. With new content, novel query capabilities, and biologist-friendly data summaries and visualization, PomBase also drives innovation in the MOD community